Claritin-D®
Efficacy

 

Claritin-D®
Efficacy

Nasal Congestion: A Key Unmet Need in Allergic Rhinitis

  • Top patient concern: 4 in 10 rate nasal congestion as their most severe symptom.1
  • Top HCP concern: 9 in 10 say it’s the most troublesome for their patients.2

 

Nasal Congestion: A Key Unmet Need in Allergic Rhinitis

  • Top patient concern: 4 in 10 rate nasal congestion as their most severe symptom.1
  • Top HCP concern: 9 in 10 say it’s the most troublesome for their patients.2

 

Why Patients Are Dissatisfied with Competitive Products

Despite treatment options, many still struggle with congestion relief3,4 due to:

  • Incomplete relief5
  • Perceived ineffectiveness5
  • Slow onset4
  • Short duration5
  • Side effects5
  • Misunderstood expectations of fast relief from intranasal steroids6

Why Patients Are Dissatisfied with Competitive Products

Despite treatment options, many still struggle with congestion relief3,4 due to:

  • Incomplete relief5
  • Perceived ineffectiveness5
  • Slow onset4
  • Short duration5
  • Side effects5
  • Misunderstood expectations of fast relief from intranasal steroids6

Claritin-D® Provides Significant Relief for Patients
with Allergic Rhinitis with Nasal Symptoms7

Claritin-D® Provides Significant Relief for Patients with Allergic Rhinitis with Nasal Symptoms7

Improvement in allergic rhinitis and nasal stuffiness with Claritin-D® chart.
Improvement in allergic rhinitis and nasal stuffiness with Claritin-D® chart.

Claritin-D® starts to work in as little as 30 minutes8

  • Onset of action for allergies with nasal congestion in as little as 30 minutes.8
  • Relief starts in 30 minutes, while an INS can take up to 12 hours for relief and can take between 3 to 14 days to reach maximum efficacy levels.8-14,§
  • In a clinical study, Claritin-D® provided significantly greater relief of nasal congestion and runny nose vs placebo.7

*Physician-evaluated scores.

†P≤0.02.

‡P≤0.05 vs placebo.

§INS onset based on various dosing instructions; time to maximum efficacy depends on the INS brand.

Adapted from Kaiser et al, 1998.

A double-blind, placebo-controlled, multicenter study involving 469 patients with mild-to-moderate SAR symptoms.

INS=intranasal steroid; SAR=seasonal allergic rhinitis.

 

In a Clinical Trial, Claritin-D® 12 Hour Provided
30% More Nasal Airflow at Hour 115,*

In a Clinical Trial, Claritin-D® 12 Hour Provided 30% More Nasal Airflow at Hour 115,*

Chart comparing average percent change in peak nasal inspiratory flow with Claritin-D® and placebo.
Chart comparing average percent change in peak nasal inspiratory flow with Claritin-D® and placebo.

*Based on max air intake through the nose after the first dose.

†P<0.05 vs corresponding placebo.

Treatment phase baseline PNIF is from the highest of 3 measured values prior to study treatment. P values and estimates at each timepoint are from a mixed effects model with sequence, period, and treatment as fixed effects and subject within sequence as a random effect.

Note: The maximum PNIF value from each timepoint is summarized.

PNIF=peak nasal inspiratory flow.

 

Claritin-D® 12 Hour Provided an
Improvement of Nasal Airflow at Least 2
Times More than Flonase at Hour 115,*

Claritin-D® 12 Hour Provided an Improvement of Nasal Airflow at Least 2 Times More than Flonase at Hour 115,*

Chart comparing average percent change in peak nasal inspiratory flow with Claritin-D® and Fluticasone nasal spray.
Chart comparing average percent change in peak nasal inspiratory flow with Claritin-D® and Fluticasone nasal spray.

*Based on max air intake through the nose after the first dose.

†P<0.05 vs fluticasone nasal spray.

Treatment phase baseline PNIF is from the highest of 3 measured values prior to study treatment. P values and estimates at each timepoint are from a mixed effects model with sequence, period, and treatment as fixed effects and subject within sequence as a random effect.

Note: The maximum PNIF value from each timepoint is summarized.

 

Claritin-D® 12 Hour:
Better Outcomes at 240 Minutes vs Flonase
or Placebo for Entire Study Duration15

Claritin-D® 12 Hour: Better Outcomes at 240 Minutes vs Flonase or Placebo for Entire Study Duration15

Chart comparing average percent change in PNIF with Claritin-D®, Fluticasone nasal spray and placebo.
Chart comparing average percent change in PNIF with Claritin-D®, Fluticasone nasal spray and placebo.

Average percent change in PNIF was significantly greater with Claritin-D® vs Flonase nasal spray or placebo throughout the study period.

P<0.05 vs fluticasone nasal spray.

†P<0.05 vs corresponding placebo.

Treatment phase baseline PNIF is from the highest of 3 measured values prior to study treatment. P values and estimates at each timepoint are from a mixed effects model with sequence, period, and treatment as fixed effects and subject within sequence as a random effect.

Note: The maximum PNIF value from each timepoint is summarized.

PNIF=peak nasal inspiratory flow.
 

 

Claritin-D® is Indicated to Relieve More Types of Allergy Symptoms than Flonase Based on Approved Label Indications

Comparison of symptoms treated with Claritin-D® and Flonase.

Claritin-D®
Patient Types

  • Patients with allergic rhinitis with nasal congestion.
  • Patients concerned about drowsiness.
  • Patients seeking once-daily treatment.
  • Patients who want nasal congestion relief.
  • Patients already on Claritin® who want to add a decongestant.
  • Patients who appreciate an oral tablet vs a spray.

 

 

 

Claritin-D®
Patient Types

Patients with allergic rhinitis with nasal congestion.

  • Patients concerned about drowsiness.
  • Patients seeking once-daily treatment.
  • Patients who want nasal congestion relief.
  • Patients already on Claritin® who want to add a decongestant.
  • Patients who appreciate an oral tablet vs a spray.

 

Order Samples and Coupons for Your Patients

Claritin® offers allergy relief for kids and adults in a variety of forms and flavors. Help your patients tackle their tough allergy symptoms with samples and coupons for Claritin® products. Your patients have options with different Claritin® products!

Order Patient Resources

 

 

Order Samples and Coupons for Your Patients

Claritin® offers allergy relief for kids and adults in a variety of forms and flavors. Help your patients tackle their tough allergy symptoms with samples and coupons for Claritin® products.

Order Patient Resources

 

 

References
  1. Meltzer EO, Farrar JR, Sennett C. Findings from an online survey assessing the burden and management of seasonal allergic rhinoconjunctivitis in US patients. J Allergy Clin Immunol Pract. 2017;5(3):77-789. doi:10.1016/j.jaip.2016.10.010
  2. Blaiss MS, Meltzer EO, Derebery MJ, Boyle JM. Patient and healthcare-provider perspectives on the burden of allergic rhinitis. Allergy Asthma Proc. 2007;28(Suppl 1):S4-S10. doi:10.2500/aap.2007.28.2991
  3. Meltzer EO, Blaiss MS, Naclerio RM, et al. Burden of allergic rhinitis: allergies in America, Latin America, and Asia-Pacific adult surveys. Allergy Asthma Proc. 2012;33(Suppl 1):S113-S141. doi:10.2500/aap.2012.33.3603
  4. Keith PK, Desrosiers M, Laister T, Schellenberg RR, Waserman S. The burden of allergic rhinitis (AR) in Canada: perspectives of physicians and patients. Allergy Asthma Clin Immunol. 2012;8(1):1-11. doi:10.1186/1710-1492-87
  5. Meltzer EO, Blaiss MS, Derebery MJ, et al. Burden of allergic rhinitis: results from the Pediatric Allergies in America survey. J Allergy Clin lmmunol. 2009;124(3 Suppl):S43-S70. doi:10.1016/j.jaci.2009.05.013
  6. Bousquet J, et al. Allergic rhinitis and its impact on asthma (ARIA) update. Allergy. 2008;63(suppl 86):8‑160.
  7. Kaiser HB, Banov CH, Berkowitz RR, et al. Comparative efficacy and safety of once-daily versus twice-daily loratadine-pseudoephedrine combinations versus placebo in seasonal allergic rhinitis. Am J Ther. 1998;5(4):245-251.
  8. Georgitis JW, Meltzer EO, Kaliner M, Weiler J, Berkowitz R. Onset-of-action for antihistamine and decongestant combinations during an outdoor challenge. Ann Allergy Asthma lmmunol. 2000;84(4):451-459.
  9. Flonase® website. Accessed February 17, 2026. 
  10. Flonase® Prescribing Information. GlaxoSmithKline; 2019.
  11. Flonase® website. Accessed February 17, 2026.
  12. Nasacort® website. Accessed December 8, 2021. 
  13. Nasacort® Prescribing Information. Sanofi-Aventis; 2008.
  14. Rhinocort® website. Accessed December 8, 2021.
  15. Ng CC, Romaikin D, Steacy LM, et al. Comparative nasal airflow with loratadine-pseudoephedrine and fluticasone nasal spray for allergic rhinitis. Ann Allergy Asthma Immunol. 2021;S1081-1206(21)00348-3. doi:10.1016/j.anai.2021.05.001
  16. Claritin-D® 12 Hour Drug Facts. NDA019670.
  17. Flonase® Drug Facts. NDA205434.